Plenary P1: Chair - Ray Norton
Yehu Moran (Hebrew University of Jerusalem, Israel)
Genetic manipulation of a sea anemone unravels how venom shapes interspecific interactions and evolutionary tradeoffs

Session A (Auditorium 2)
Advances and Applications of Omics in Toxinology
Chair: Juan Calvete

Session B (Auditorium 1)
Epidemiology and Prevention of Envenoming and Poisoning 1
Chair: David Williams

Keynote Speaker A1:
Juan Calvete (Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain)
The long journey of a heterodimeric beta-neurotoxic PLA2 family: a multi-disciplinary and multi-omics perspective

Keynote Speaker B1:
Aniruddha Ghose (Chittagong Medical College and Hospital, Bangladesh)
Snakebite epidemiology – findings from a nationally conducted survey in Bangladesh

Invited Speaker I1:
Renaud Vincentelli (CNRS-Aix-Marseille University, France)
ADDovenom : Thermostable protein-based ADDomer nanoparticles as new therapeutics for snakebite envenoming

11.00 am

Oral Presenter A1:
Matyas A Bittenbinder (Vrije Universiteit Amsterdam, The Netherlands)
Bloody insights: using organ-on-chip technology to study haemorrhagic activities of snake venoms on endothelial tubes

Oral Presenter A2:
Isabel Batista (Butantan Institute, São Paulo, Brazil)
The development of a micro method that optimizes venom fractionation for proteomic analysis

Oral Presenter A3:
Juan Carlos G. Galindo (Universidad de Cádiz, Puerto Real, Spain)
Amphinomid-eater cone snails: is conotoxins intraspecific variability a fact? A case study of two Rhombiconus species

Oral Presenter A4:
Michelle Khai Khun Yap (Monash University Malaysia, Bandar Sunway, Malaysia)
Epitope-Omics directed discovery of Apt6: Neutralisation effects against cobra venom

Oral Presenter B1:
Khin Than Yee (Department of Medical Research, Yangon, Myanmar)
Clinico-epidemiological profile of snake bite in children and adolescents from tertiary hospitals in Yangon, Myanmar

Oral Presenter B2:
Deb Prasad Pandey (Institute for Social and Environmental Research Nepal, Chitwan, Nepal)
Expenditure of snakebite care and its impact on household economy in Nepal

Oral Presenter B3:
Godpower C. Michael (Aminu Kano Teaching Hospital (AKTH) Kano, Nigeria)
Examining the lifetime prevalence and knowledge of snakebite among recent graduates in Nigeria

Oral Presenter B4:
Michela L. Mitchell (Women’s and Childrens Health Network, Adelaide, South Australia)
The whole venom spectra: Venom evolution to bio-applications

Session A (Auditorium 2)
Molecular Evolution and Ecology in Toxinology 1
Chair: Yehu Moran

Session B (Auditorium 1)
Epidemiology and Prevention of Envenoming and Poisoning 2
Chair: Abdul Razaq

Keynote Speaker A2:
Wolfgang Wüster (Bangor University, UK)
Venom at the interface between snake and environment: what drives venom evolution?

Keynote Speaker B2:
Sara Patidar (University of Eswatini)
Killing in cold blood - using national snakebite epidemiological data to model risks and develop community-led prevention strategies to get to zero deaths and disabilities from snakebite

Invited Speaker A2:
Cassandra Modahl (Liverpool School of Tropical Medicine, UK)
Distinct regulatory networks control toxin gene expression in elapid and viperid snakes

Invited Speaker A3:
Juan David Bayona Serrano (Butantan Institute, Brazil)
Same old scaffolds, new genes: the convergent solutions of Dipsadidae snake venoms

Oral Presenter A5:
Mrinalini Walter (National University of Singapore, Singapore)
The origins and evolution of snake venom: elucidations from the chromosome-level genome of Tropidolaemus wagleri

Oral Presenter A6:
Manal Siyam (Amsaal Venom Company, Abu Dhabi, UAE)
Unravelling the diversity and evolution of venomous scorpions: The re-classification of Buthus occitanus complex and insights to scorpion antivenom development

Oral Presenter A7:
Laura-Oana Albulescu (Liverpool School of Tropical Medicine, UK)
Small molecule therapeutics for neutralising venom toxins - a drug discovery approach

Oral Presenter B5:
Dhirubai C Patel (Gujarat, India)
What I have learnt in three decades of snakebite management: my clinico-epidemiological journey

Oral Presenter B6:
Joao Ricardo Nickenig Vissoci (Duke University School of Medicine, Durham, North Carolina, USA)
Integrating health and climate data to enhance snakebite envenomation response strategies in Brazil's Amazon

Oral Presenter B7:
Stella Regina Zamuner (Universidade Nove de Julho, São Paulo, Brazil)
Myogenic enhancement and inflammation control: Photobiomodulation's action against Bothrops jararacussu venom in myoblast cells

Session A (Auditorium 2)
Molecular Evolution and Ecology in Toxinology 2
Chair: Wolfgang Wüster

Session B (Auditorium 1)
Epidemiology and Prevention of Envenoming and Poisoning 3
Chair: David Williams

Keynote Speaker A3:
Kartik Sunagar (Indian Institute of Science, Bengaluru, India)
To eat, or not to eat: The evolution of toad toxin resistance in Serpentes

Keynote Speaker B3:
Wuelton Monteiro (Amazonas State University, Manaus, Brazil)
Humans and Snakes within the Indigenous Perspectivism in the Amazon: Proposal for a Antivenom Decentralization Program

Invited Speaker A4:
Eivind Undheim (University of Oslo, Norway)
Lacewing venom: Detailed insights into the venom system of a neglected group of venomous insects

Invited Speaker A5:
Joachim Surm (Ludwig Maximillians University of Munich, Germany)
Sea anemone MACPF proteins demonstrate an evolutionary transitional state between venomous and developmental functions

NextGen Talks (Flash talks)
Chair: Cassandra Modahl
Timer: Nadia Loh Ting Wei

Lennart Schulte (Justus Liebig University of Giessen, Germany)
Venomics of the Milos viper (Macrovipera schweizeri)

Anurag Jaglan (Indian Institute of Science, Bengaluru, India)
The Hidden Arsenal: Venomics and antivenomics of medically important yet neglected snakes from India

Uthpala Chandrasekara (University of Queensland, St Lucia, Australia)
Venom versus varanid: A chemical arms race in Australia's reptilian realm

Anders Isaksen (University of Oslo, Norway)
Genome of a single worker of the greenhead ant, Rhytidoponera metallica, reveals mechanisms of toxin evolution in a genetically hyperdiverse eusocial species

NextGen Talks (Early Career talks)
Chair: Cassandra Modahl
Timer: Nadia Loh Ting Wei

Timothy Jackson (University of Melbourne, Australia)
On the chemical ecology and evolvability of brown snakes (genus Pseudonaja)

Anas Bedraoui (Mohammed VI Polytechnic University, Ben Guerir, Morocco)
The convergence of artificial intelligence in toxinology and venomics

Valentin M. Tabakmakher (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia)
Computer modeling of polypeptide toxins and ion channels: Achieving success through failure

NextGen Talks (Flash talks)
Chair: Steve Peigneur
Timer: Cody Chew Ming Yee

Sri Teja Adheda (Indian Institute of Science, Bengaluru, India)
Mapping the conformational space of rare disulphide bonded conotoxins

Yachen Wang (University of the Sunshine Coast, Sippy Downs, Australia)
Developing a soybean leaf disc assay for discovering oral insecticidal venom peptides against Helicoverpa armigera pest caterpillars

Haifeng Xu (Vrije Universiteit Amsterdam, The Netherlands)
Cytotoxicity profiling of toxins in snake venoms enabled by nanofractionation analytics and high throughput venomics

Lou Freuville (University of Liège, Belgium)
Identification of potential anticancer peptides from animal venoms using mass spectrometry techniques

NextGen Talks (Early Career talks)
Chair: Steve Peigneur
Timer: Cody Chew Ming Yee

Tihana Kurtovic (University of Zagreb, Croatia)
Intramuscular vs intravenous antivenom ̵ on the path of revealing the better weapon in the fight against venom

Tim Lüddecke (Fraunhofer Institute for Molecular Biology and Applied Ecology, Giessen, Germany)
Bioactivity profiling of novel pseudoscorpion toxins with antimicrobial activity: From biological considerations to future anti-infective applications

Stephanie French (Liverpool School of Tropical Medicine, UK)
Identification of endogenous mediators contributing to snake venom-induced cytotoxicity

Plenary P2: Chair - David Warrell
R. Manjunatha Kini (National University of Singapore, Singapore)
Origin and accelerated evolution of snake venom toxins

Session C (Auditorium 2)
Invertebrate Toxinology
Chair: Ronald Jenner/Jan Tytga

Session D (Auditorium 1)
Microbial Toxinology
Chair: Ornella Rossetto

Keynote Speaker C1:
Jordi Molgo (Université Paris-Saclay, France)
Invertebrate and dinoflagellate marine toxins targeting signaling and key components of the skeletal neuromuscular system of vertebrates

Keynote Speaker D1:
Ornella Rossetto (University of Padova, Italy)
The effects of botulinum neurotoxins in the intestine in a mouse model of foodborne botulism

Keynote Speaker C2:
Ronald Jenner (Natural History Museum, London, UK)
What is animal venom? Reassessing a manipulative weapon

Keynote Speaker D2:
Alexander Vassilevski (Russian Academy of Sciences, Moscow, Russia)
P2X3 receptor-inhibitory peptides from spider venom

Invited Speaker C1:
Zhijian Cao (Hubei University of Technology, Wuhan, China)
Molecular and neural mechanisms of the itchy effect induced by defensin peptides from ticks and fungi

Invited Speaker C1:
Lakshminarayanan Rajamani (Singapore Eye Research Institute, Singapore)
Enhancing the microbial membrane selectivity of cytotoxic peptides by isolysine substitution

Oral Presenter C1:
Volker Herzig (University of Queensland, Brisbane, Australia)
Exploring sublethal effects of insecticides on contextual memory of insects

Oral Presenter C2:
Evelyne Benoit (Université Paris-Saclay, CEA, Gif-sur-Yvette, France)
A new potent peptide blocker, from Poecilotheria subfusca spider, of the human Cav1.2 channel subtype

Oral Presenter D1:
Amparo Alfonso (Universidad de Santiago de Compostela, Spain)
Evaluation of single and combined effects of emerging mycotoxins in neuronal cells

Oral Presenter D2:
Karleigh Hamblin (Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, UK)
Development of a saxitoxin activity assay

City Tour

• 4.00PM: Pick up from NUS UTown Stephen Riady Centre
• 8.00 PM: Drop off at Gardens by the bay
  (transportation back to hotel/NUS Student Hostel at your own expense)
• City Tour including China Town, Kampong Glam, and Little India, Indian Heritage Centre and Merlion if time permits.

Plenary P3: Chair - Cesare Montecucco
Solange M. T. Serrano (Butantan Institute, São Paulo, Brazil)
Systemic analysis of the pathological effects of a snake venom and of an antivenom, in a murine model of envenoming

Session E (Auditorium 2)
Mechanism of Action and Pathophysiology of Toxins 1
Chair: Igor Križaj

Session F (Auditorium 1)
Clinical Aspects of Toxinology 1
Chair: David Warrell

Keynote Speaker E1:
Ray Norton (Monash University, Parkville, Australia)
Kv1.3-inhibitory peptides from sea anemones and scorpions: therapeutic development and role of dynamics in channel blockade

Keynote Speaker F1:
Ahmad Khaldun Ismail (Universiti Kebangsaan Malaysia, Hospital Canselor Tuanku Muhriz, Kuala Lumpur, Malaysia)
Advancing Clinical Toxinology in ASEAN: From Neglect to Action

Invited Speaker E1:
Denis Servent (Université Paris-Saclay, Gif-sur-Yvette, France)
Biodistribution of pinnatoxin-G in vivo and study of how this highly potent nAChR antagonist crosses the blood-brain and placental barriers

Oral Presenter E1:
Fernanda Cardoso (University of Queensland, Brisbane, Australia)
Venom peptides unlock dysfunctional ion channels in motor neurodegeneration and shed light onto pathophysiology and key drug targets

Oral Presenter E2:
Ekaterina Lyukmanova (Russian Academy of Sciences, Moscow, Russia)
Spatial structure, analgesic effects, and TRPA1 modulation of the Kunitz-type sea-anemone peptide HCIQ2C1

Oral Presenter E3:
Zakhar Shenkarev (Russian Academy of Sciences, Moscow)
Structure, function, and interaction with membranes and TRPA1 channel of Phα1β toxin from the Brazilian armed spider

Oral Presenter E4:
Steve Peigneur (University of Leuven (KU Leuven), Belgium)
Functional characterization of a novel ion channel toxin from the longest animal on earth

Oral Presenter F1:
Choo Hock Tan (National Tsing Hua University, Hsinchu, Taiwan)
Translating snake venomics in Asia: Latest development and future directions

Oral Presenter F2:
Denise Ann Caballes (University of the Philippines - Philippine General Hospital, Manila, Philippines)
Tetrodotoxin and saxitoxin poisoning in the Philippines

Oral Presenter F3:
Ren Lai (Kunming Institute of Zoology, Yunnan, China)
Tick saliva interference with LTβR signaling facilitates the transmission of Lyme disease spirochetes

Oral Presenter F4:
Nicolas Gilles (Université Paris Saclay, CEA, Gif-sur-Yvette, France)
Exploiting snake toxin-derived positron emission tomography agents for diagnosing metastatic clear cell renal cell carcinoma

Session E (Auditorium 2)
Mechanism of Action and Pathophysiology of Toxins 2
Chair: Solange Serrano

Session F (Auditorium 1)
Clinical Aspects of Toxinology 2
Chair: Jaideep Menon

Keynote Speaker E2:
Ana Moura-da-Silva (Butantan Institute, São Paulo, Brazil)
Complexity of the biological effects of viper venoms: origin and diversification of snake venom metalloproteinases (SVMPs) in Bothrops snakes

Keynote Speaker F2:
David A Warrell (Nuffield Department of Clinical Medicine, University of Oxford, UK)
Novelty and crisis in Clinical Toxinology: Ecstasy and Agony!

Invited Speaker E2:
Shrinivasan Raghuraman (University of Utah, Salt Lake City, Utah, USA)
Constellation pharmacology: Integrating natural products, molecular targets and biological functions

Invited Speaker E3:
Eliane C. Arantes (University of São Paulo, Ribeirão Preto, Brazil)
Synergistic action of toxins from Tityus serrulatus scorpion venom

Oral Presenter E5:
Narumi Aoki-Shioi (Fukuoka University, Japan)
Mechanism of synergistic function of Dendroaspis angusticeps-type toxins

Oral Presenter E6:
Keitaro Kitazato (Fukuoka University, Japan)
Molecular mechanisms of hemorrhagic toxicity induced by snake venom metalloproteinase isozymes in Protobothrops flavoviridis venom

Oral Presenter E7:
Siddhartha P Sarma (Indian Institute of Science, Bangalore, Karnataka, India)
Structure and Function of a potent subtilisin inhibitor from Budgett's frog, Lepidobatrachus laevis

Oral Presenter F5:
Juliana P. Zuliani (Universidade Federal de Rondônia, Porto Velho-Rondônia, Brazil)
Effectiveness of red and infrared low-intensity laser therapy (LLLT) for reducing local manifestations by Bothrops envenoming in patients at the Tropical Medicine Center of Rondônia (Cemetron)

Oral Presenter F6:
Stuart Ainsworth (Liverpool School of Tropical Medicine, UK)
Progress on improving animal welfare and experiment translatability using an animal model of venom induced consumption coagulopathy

Oral Presenter F7:
Nicholas Hurst (University of Arizona, Tucson, USA)
Should they stay or should they go?: description of the largest open-label scorpion antivenom clinical trial reported to the National Poison Data System

Session E (Auditorium 2)
Mechanism of Action and Pathophysiology of Toxins 3
Chair: Solange Serrano

Session F (Auditorium 1)
Clinical Aspects of Toxinology 3
Chair: David Warrell

Keynote Speaker E3:
Igor Križaj (Jožef Stefan Institute, Ljubljana, Slovenia)
Reversible thrombocytopenia of functional platelets after the nose-horned viper venom envenomation is induced by a snaclec

Keynote Speaker F3:
Jaideep Menon (Amrita Institute of Medical Sciences and Research Centre, Kochi, India)
National study on the incidence, mortality, morbidity and socioeconomic burden of SBE in India

Invited Speaker E4:
Johannes Eble (University of Münster, Germany)
Snake venom components prevents platelets from being hijacked by tumor cells

Invited Speaker E5:
Cho Yeow Koh (National University of Singapore, Singapore)
A-B-C-D-K-N-P-G-R-S-F-Y: Alphabet soup for the failing heart, seasoned with toxins from krait venom

NextGen Talks (Flash talks)
Chair: Steve Peigneur
Timer: Nadia Loh Ting Wei

Che Yuqi (Shenzhen MSU-BIT University, China)
Human protoxin PSCA inhibits growth and invasion of glioblastom

Kai Xuan Chan (National University of Singapore, Singapore)
Isolation and characterization of a novel inhibitor of coagulation complexes from the venom of the black-necked spitting cobra, Naja nigricollis

Miguel Engelhardt (University of Münster, Germany)
Inhibition of cancer induced coagulation and thrombosis by snake venom proteins

Olga V Shlepova (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia)
Human toxin-like SLURP-1 protein as a prototype of anticancer drugs: Molecular mechanisms of action in vivo

Romain Baudat (Université Paris-Saclay, CEA, Gif-sur-Yvette, France)
Venom peptides as promising tools for lung cancer diagnosis

NextGen Talks (Early Career talks)
Chair: Steve Peigneur
Timer: Nadia Loh Ting Wei

Jessica Muller (University of Queensland, Brisbane, Australia)
Voltage-gated sodium channel 1.6 as a novel target for amyotrophic lateral sclerosis treatment

Alexey Kuzmenkov (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia)
Tarantula toxin inhibits potassium channels by the pore occlusio

Andrea Seldeslachts (Catholic University of Leuven, Belgium)
Beyond the stings: Decoding the venom of the oak processionary caterpillar and navigating therapeutic innovation through TRPV1 channel insights

NextGen Talks (Flash talks)
Chair: Cassandra Modahl
Timer: Cody Chew Ming Yee

Max Overath (Technical University of Denmark, Denmark)
Yeast-display-guided high-throughput discovery of cross-binding V_H against snake venom toxins

Mimi Lay (Monash University, Clayton, Australia)
The efficacy of antivenom and Varespladib against the in vitro pre-synaptic neurotoxicity of Javanese Russell’s viper (Daboia siamensis) venom

Christabel Chan (National University of Singapore, Singapore)
Three-finger toxins as selective probes to distinguish subunit interfaces of nicotinic acetylcholine receptors

Nivedita Kolvekar (BITS Pilani, K K Birla Goa Campus, India)
Cytotoxic agents from Vipera russelli russelli venom

Navaneel Sarangi (Indian Institute of Science, Bengaluru, India)
Significant serpents: Modelling bioclimatic venom variation in Daboia russelii

NextGen Talks (Early Career talks)
Chair: Cassandra Modahl
Timer: Cody Chew Ming Yee

Melisa Benard-Valle (Technical University of Denmark, Denmark)
In vivo neutralization of neurotoxic snake venoms with defined mixtures of broadly-neutralizing nanobodies

Dan Liao (National University of Singapore, Singapore)
Efficacy of novel anticoagulants derived from tick saliva in preventing hypercoagulation among post-acute COVID-19 patients

Tarek Mohamed Abd El-Aziz
Next-generation biotechnological therapy for developing an affordable therapy for in vitro and in vivo modulation of αC-Conotoxin PrXA

Plenary P4: Chair - Jordi Molgó
Glenn King (University of Queensland, Brisbane, Australia)
Deadly cures: a drug candidate to treat ischemic injuries the heart and brain from venom of the lethal Australian funnel-web spider

Session G (Auditorium 2)
Translation of Toxinology in Medicine and Biotechnology
Chair: R. Manjunatha Kini

Session H (Auditorium 1)
Marine Toxins
Chair: Richard Lewis

Keynote Speaker G1:
Tur-Fu Huang (National Taiwan University, Taiwan)
The potential application of disintegrin variants in arterial thrombosis and ischemic inflammatory diseases

Keynote Speaker H1:
Richard Lewis (University of Queensland, Brisbane, Australia)
Ciguatera fish poisoning: origins, pathophysiology and management

Keynote Speaker G2:
Andreas Vilcinskas (Fraunhofer Institute, Giessen, Germany)
Drugs from bugs: insect biotechnology based venomics

Invited Speaker A2:
Angel A. Yanagihara (University of Hawai’i at Mānoa, Honolulu, Hawai’i, USA)
Elucidation of medusozoan (jellyfish) venom constituent activities using constellation pharmacology

Oral Presenter G1:
Gregor Anderluh (Kemijski inštitut, Ljubljana, Slovenia)
Utilization of pore-forming toxins in advanced sensing technologies

Oral Presenter G2:
Ashis K. Mukherjee (Tezpur University, Tezpur, Assam, India)
Venomous elixir: unveiling snake venom-inspired neuroprotective peptides

Oral Presenter H1:
Manuel J. Tenorio (Universidad de Cádiz, Puerto Real, Spain)
Comprehensive proteotranscriptomic characterization of the venom of West African cone snails of the genus Kalloconus (Gastropoda, Conidae)

TO-AND-FRO Bus Service provided at the following location:

1. Bus Pick-up at Stephen Riady Centre
   Meet at Drop off point @ 4.30pm

2. Bus Pick-up at Park Avenue Rochester & Citadines Connect Rochester
   Near the roadside of Park Avenue Rochester @ 5.45pm

3. Bus Pick-up at Citadines Science Park Singapore
   Lobby @ 5.45pm

4. Bus Pick-up at Momentus Hotel Alexandra
   Lobby @ 5.45pm

Plenary P5: Chair - David Adams
Pedro Alexandrino Fernandes (University of Porto, Portugal)
The molecular mechanism of action of snake venom toxins - a computational perspective

Session I (Auditorium 2)
Novel Therapeutic Approaches of Envenoming
Chair: Jeroen Kool

Keynote Speaker I1:
Jeroen Kool (Vrije Universiteit Amsterdam, Holland)
Analytics for discovery and assistance in development of new snakebite treatments

Keynote Speaker I2:
Constantinos Kurt Wibmer (University of the Witwatersrand, Johannesburg, South Africa)
Monoclonal antibodies neutralizing snake venom long and short chain three finger neurotoxins

Oral Presenter I1:
Dmitry Umerenkov (Artificial Intelligence Research Institute, Moscow, Russia)
SEMA 2.1: Web-platform dedicated to epitope prediction and analysis

Oral Presenter I2:
Devadasan Velmurugan (SRM Institute of Science and Technology,
Kattankulathur, Tamil Nadu, India)
Herbal antidotes for Indian snake bites

Oral Presenter I3:
Cesare Montecucco (University of Padova, Italy)
Agonists of the CXCR4 and the MT1 receptors greatly accelerate the recovery of respiration after the neuroparalysis induced by neurotoxic snake envenomings

Oral Presenter I4:
Stanislaw Pikul (Pikralida, Uniwersytetu Poznanskiego, Poznan, Poland)
A Phase I clinical study of single and multiple doses of Marimastat (PKL-021) administered orally to healthy subjects

NextGen Networking Session
(Dance Atelier, Level 3)

Arrival of participants; seated in Discussion Groups

Introductions and ice-breaker activity

Discuss questions pertaining to careers in the field and the future of toxinology

Consolidate discussion points

Each group presents a summary of their discussion